189469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 705904..706547 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN141_RS03215 Protein ID WP_003403187.1
Coordinates 706146..706547 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN141_RS03210 Protein ID WP_003403184.1
Coordinates 705904..706149 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS03175 701184..701714 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN141_RS03180 701698..702393 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN141_RS03185 702516..702827 + 312 WP_003403164.1 hypothetical protein -
JN141_RS03190 702899..703849 + 951 WP_003900184.1 DUF1259 domain-containing protein -
JN141_RS03195 704090..704674 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN141_RS03200 704676..705386 + 711 Protein_632 IS607 family element RNA-guided endonuclease TnpB -
JN141_RS03205 705389..705859 + 471 WP_003898523.1 hypothetical protein -
JN141_RS03210 705904..706149 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN141_RS03215 706146..706547 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN141_RS03220 706538..706717 + 180 Protein_636 hypothetical protein -
JN141_RS03225 707135..707332 - 198 WP_003403191.1 hypothetical protein -
JN141_RS03230 707412..708569 - 1158 WP_031650816.1 hypothetical protein -
JN141_RS03235 708621..708842 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN141_RS03240 708984..709589 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189469 WP_003403187.1 NZ_CP069072:706146-706547 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189469 NZ_CP090778:c1227490-1227191 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGTCTTACACGTACAA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189469 WP_003403184.1 NZ_CP069072:705904-706149 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189469 NZ_CP090778:c1227725-1227480 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGACCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References