Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 697499..698145 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag JN141_RS03145 Protein ID WP_003403122.1
Coordinates 697499..697891 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag JN141_RS03150 Protein ID WP_003403125.1
Coordinates 697888..698145 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS03130 693161..694687 + 1527 WP_003403112.1 virulence factor Mce family protein -
JN141_RS03135 694750..695892 + 1143 WP_003911253.1 virulence factor Mce family protein -
JN141_RS03140 695897..697447 + 1551 WP_003403119.1 MlaD family protein -
JN141_RS03145 697499..697891 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
JN141_RS03150 697888..698145 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
JN141_RS03155 698328..699563 - 1236 WP_003403128.1 ATP-binding protein -
JN141_RS03160 699814..700227 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
JN141_RS03165 700224..700460 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
JN141_RS03170 700564..701070 - 507 WP_003900973.1 two component system sensor kinase HK1 -
JN141_RS03175 701184..701714 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN141_RS03180 701698..702393 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN141_RS03185 702516..702827 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T189467 WP_003403122.1 NZ_CP069072:c697891-697499 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T189467 NZ_CP090778:792027-792446 [Burkholderia multivorans]
ATGATCCTTGTCGATACGAACGTCATTTTCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
CCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGAC
GCCGGCGGGACTGGCTGGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT189467 WP_003403125.1 NZ_CP069072:c698145-697888 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT189467 NZ_CP090778:791857-792030 [Burkholderia multivorans]
CTGCACGGGCGCAGTACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGG
AACCTTGCTGGCGGAAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCGAACCGACCCGA
TGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References