Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 680370..680989 Replicon chromosome
Accession NZ_CP069072
Organism Mycobacterium tuberculosis strain N1216

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag JN141_RS03080 Protein ID WP_003403047.1
Coordinates 680582..680989 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag JN141_RS03075 Protein ID WP_003403039.1
Coordinates 680370..680585 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN141_RS03065 678898..679656 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
JN141_RS03070 679785..680276 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
JN141_RS03075 680370..680585 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
JN141_RS03080 680582..680989 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
JN141_RS03085 681049..681735 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
JN141_RS03090 681889..684522 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T189466 WP_003403047.1 NZ_CP069072:680582-680989 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T189466 NZ_CP090778:c630850-630272 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGCCCGAGCAAGCCGCGCATCCGGACAAGAACATGCACGAACGCGACGACCTGCTCACGTTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAGCTCGTCGCACTGTGGGACGAATACGACGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGACTAC
GGCCGGCGCTATACGGATGCGGCACCGCTGTTCAGCGCGATCCGCGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACAAACGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT189466 WP_003403039.1 NZ_CP069072:680370-680585 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT189466 NZ_CP090778:c631542-630985 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTGGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCACCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTCGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAGATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGATTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCGTCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGATCGGCGGCACGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References