Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pezAT/zeta-ParD |
Location | 446906..447917 | Replicon | chromosome |
Accession | NZ_CP069072 | ||
Organism | Mycobacterium tuberculosis strain N1216 |
Toxin (Protein)
Gene name | pezT | Uniprot ID | L7N5R2 |
Locus tag | JN141_RS01950 | Protein ID | WP_003401859.1 |
Coordinates | 446906..447499 (-) | Length | 198 a.a. |
Antitoxin (Protein)
Gene name | pezA | Uniprot ID | O53702 |
Locus tag | JN141_RS01955 | Protein ID | WP_003401860.1 |
Coordinates | 447528..447917 (-) | Length | 130 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN141_RS01930 | 442555..443937 | + | 1383 | WP_003898415.1 | magnesium transporter | - |
JN141_RS01935 | 443949..444983 | - | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
JN141_RS01940 | 445079..445762 | + | 684 | WP_003401857.1 | VTT domain-containing protein | - |
JN141_RS01945 | 445751..446881 | - | 1131 | WP_003401858.1 | glycoside hydrolase family 76 protein | - |
JN141_RS01950 | 446906..447499 | - | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
JN141_RS01955 | 447528..447917 | - | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
JN141_RS01960 | 447998..449209 | - | 1212 | WP_003906353.1 | VWA domain-containing protein | - |
JN141_RS01965 | 449215..449817 | - | 603 | WP_003898417.1 | SRPBCC family protein | - |
JN141_RS01970 | 449831..450727 | - | 897 | WP_003898418.1 | MoxR family ATPase | - |
JN141_RS01975 | 450724..451317 | - | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
JN141_RS01980 | 451314..452069 | - | 756 | WP_003401865.1 | XdhC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T189464 WP_003401859.1 NZ_CP069072:c447499-446906 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
>T189464 NZ_CP090776:c1564719-1564300 [Burkholderia multivorans]
ATGATCCTTGTTGATACGAACGTCATTTCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTCGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCATGGGCCTCATAG
ATGATCCTTGTTGATACGAACGTCATTTCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTCGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCATGGGCCTCATAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT189464 WP_003401860.1 NZ_CP069072:c447917-447528 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
>AT189464 NZ_CP090776:c1564955-1564716 [Burkholderia multivorans]
ATGCCTGTGATTACCGTTCGAAACTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGTGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGTGTCGATTTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA
ATGCCTGTGATTACCGTTCGAAACTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGTGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGTGTCGATTTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BRT0 |