Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3790325..3790992 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag JN142_RS17860 Protein ID WP_003417916.1
Coordinates 3790325..3790717 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag JN142_RS17865 Protein ID WP_003912214.1
Coordinates 3790717..3790992 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS20685 3785546..3787156 - 1611 WP_003417910.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
JN142_RS20690 3787101..3787382 - 282 WP_003914149.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
JN142_RS17845 3787379..3788083 - 705 Protein_3528 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN142_RS17850 3788085..3788519 - 435 Protein_3529 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN142_RS17855 3788519..3789571 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
JN142_RS17860 3790325..3790717 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS17865 3790717..3790992 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN142_RS17870 3791174..3792545 + 1372 Protein_3533 ISNCY family transposase -
JN142_RS17875 3792735..3794930 + 2196 WP_010886168.1 PE family protein -
JN142_RS17880 3795001..3795873 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3791868..3792545 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T189458 WP_003417916.1 NZ_CP069071:c3790717-3790325 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T189458 NZ_CP090774:3401786-3402037 [Burkholderia multivorans]
ATGCAACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCAGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCTCGATGGCGATACCGTCACGATTTTGGCCGTGCGGCACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT189458 WP_003912214.1 NZ_CP069071:c3790992-3790717 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT189458 NZ_CP090774:3401481-3401759 [Burkholderia multivorans]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGAGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References