Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2360901..2361596 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN142_RS11035 Protein ID WP_003410811.1
Coordinates 2360901..2361335 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN142_RS11040 Protein ID WP_003410814.1
Coordinates 2361342..2361596 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS11025 2357135..2360096 + 2962 Protein_2180 DEAD/DEAH box helicase -
JN142_RS11030 2360089..2360922 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN142_RS11035 2360901..2361335 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS11040 2361342..2361596 - 255 WP_003410814.1 antitoxin Antitoxin
JN142_RS11045 2361612..2361869 - 258 WP_003410816.1 hypothetical protein -
JN142_RS11050 2362816..2363112 + 297 WP_003410820.1 PE family protein -
JN142_RS11055 2363168..2363899 + 732 WP_003900467.1 PPE family protein -
JN142_RS11060 2364439..2365185 - 747 WP_003906749.1 proteasome subunit alpha -
JN142_RS11065 2365182..2366057 - 876 WP_003411023.1 proteasome subunit beta -
JN142_RS11070 2366054..2366248 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189439 WP_003410811.1 NZ_CP069071:c2361335-2360901 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189439 NZ_CP090768:c50837-50430 [Burkholderia multivorans]
ATGAGCCTCTATCTGCTCGACACCAATATTTTGTCGAACGTGATCCGAGACCCACGGGGCGCATGCGCTTCGCGCATCGG
GGAAACGCGGCCCGAGCAAGTGTGCACCTCGATCGTCGTCGCGGCCGAGCTACGGTACGGCGTCTGTAAGCGCGGCTCCT
CGGCGCTCGCCCAGCGTGTCGAGCAGCTGCTCGCGAGCTTGACCGTATTACCGCTGCAGTCCGACGCGGATCAGTGCTAC
GGGCGGCTGCGAGCCGATCTCGAGAGGCAGGGTCAGTTGATCGGGGCGAACGACATGCTGATCGCTGCCCACGCGATGGC
CGTCGACGCCGTCTTGGTCACGGACAATACGGCCGAATTCACTCGCGTTACAGGACTCGCCGTCGAAAACTGGCTCCGGC
CTGCGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189439 WP_003410814.1 NZ_CP069071:c2361596-2361342 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189439 NZ_CP090768:c51076-50834 [Burkholderia multivorans]
ATGCCAACCCATGACACCCGCCACGCACGCCTATTTCGCAACGGACGTAGCCAGGCCGTGCGGATCCCGCGCGAGTTCGA
GCTGCCGGTCTCGGAAGTCACTATTCATCGTGAAGGCCGGCGCCTAATCATCGAACCGGTCGAAGCGCCGTCTCTACGCG
AGCTATTTGCGCAATGGGCGCCCTTGGACGAAACTTTCCCTGACATCGAAAACCTCCCCGCTGAACCGGTCGATATTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References