Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2217244..2217932 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN142_RS10380 Protein ID WP_003409958.1
Coordinates 2217244..2217663 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN142_RS10385 Protein ID WP_003409968.1
Coordinates 2217672..2217932 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS10360 2212739..2213587 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
JN142_RS10365 2213550..2214995 - 1446 WP_003899115.1 APC family permease -
JN142_RS10370 2215174..2215860 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN142_RS10375 2216051..2217019 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN142_RS10380 2217244..2217663 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS10385 2217672..2217932 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN142_RS10390 2218075..2219751 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN142_RS10395 2219739..2220392 - 654 WP_003409976.1 cutinase Cfp21 -
JN142_RS10400 2220507..2220737 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN142_RS10405 2220822..2221733 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN142_RS10410 2221842..2222441 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189433 WP_003409958.1 NZ_CP069071:c2217663-2217244 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189433 NZ_CP090765:c1218381-1218082 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189433 WP_003409968.1 NZ_CP069071:c2217932-2217672 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189433 NZ_CP090765:c1218616-1218371 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGACCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGACGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References