Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2195511..2196055 | Replicon | chromosome |
| Accession | NZ_CP069071 | ||
| Organism | Mycobacterium tuberculosis strain N0136 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN142_RS10260 | Protein ID | WP_003409896.1 |
| Coordinates | 2195511..2195807 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN142_RS10265 | Protein ID | WP_003409899.1 |
| Coordinates | 2195804..2196055 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN142_RS10205 | 2190544..2190894 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| JN142_RS10210 | 2190905..2191807 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| JN142_RS10215 | 2191828..2192019 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN142_RS10220 | 2192020..2192316 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN142_RS10225 | 2192556..2192771 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN142_RS10230 | 2192768..2193079 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN142_RS10235 | 2193053..2193574 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN142_RS10240 | 2193549..2193926 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN142_RS10245 | 2193968..2194417 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN142_RS10250 | 2194414..2194959 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN142_RS10255 | 2194848..2195462 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN142_RS10260 | 2195511..2195807 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN142_RS10265 | 2195804..2196055 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN142_RS10270 | 2196042..2196536 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN142_RS10275 | 2196696..2197103 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN142_RS10280 | 2197107..2197379 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN142_RS10285 | 2197412..2198632 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN142_RS10290 | 2199531..2200328 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189432 WP_003409896.1 NZ_CP069071:c2195807-2195511 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189432 NZ_CP090765:c1175129-1174833 [Burkholderia multivorans]
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTAAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TATCTGAAACTGACCGTCATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTAAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TATCTGAAACTGACCGTCATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189432 WP_003409899.1 NZ_CP069071:c2196055-2195804 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189432 NZ_CP090765:c1174831-1174430 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCGCGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACGGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGGCGAGGCGACCCGTTTCG
GCGAAGCAGTGTCGGCGTTCAACCGGCAAGTGAACGCGACACTCGTTGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCACTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA
ATGAAATGTCCTGCATGCGGTGCTGCCGCGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACGGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGGCGAGGCGACCCGTTTCG
GCGAAGCAGTGTCGGCGTTCAACCGGCAAGTGAACGCGACACTCGTTGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCACTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |