Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1961301..1961761 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JN142_RS09165 Protein ID WP_003898996.1
Coordinates 1961513..1961761 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JN142_RS09160 Protein ID WP_003408528.1
Coordinates 1961301..1961513 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS09145 1957779..1958966 - 1188 WP_003898992.1 nitrate transporter NarK -
JN142_RS09150 1959253..1959537 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JN142_RS09155 1959551..1961233 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JN142_RS09160 1961301..1961513 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN142_RS09165 1961513..1961761 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS09170 1961769..1962506 + 738 WP_003898997.1 hypothetical protein -
JN142_RS09175 1962600..1964300 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JN142_RS09180 1964585..1964986 - 402 WP_003408538.1 hypothetical protein -
JN142_RS09185 1964976..1965587 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T189429 WP_003898996.1 NZ_CP069071:1961513-1961761 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T189429 NZ_CP090765:c611697-611086 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCTGAACGCTTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGTGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGAGAAGAACATGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTGACGAGCTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGACGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACAAACGTCATCGCAAACACAAACGCGCACGCACCGCGCATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT189429 WP_003408528.1 NZ_CP069071:1961301-1961513 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT189429 NZ_CP090765:c612385-611828 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCACACGCCGCCGCTGGGCCCGCAGCTAAGACGCTGGCGCCTGCTACATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGACTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGGACGAACGCATCGCGCGTCGTGCCG
ATCCATCGCAGCCGATGCCGCTGGACCCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References