Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1940512..1941125 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JN142_RS09055 Protein ID WP_003408465.1
Coordinates 1940512..1940901 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JN142_RS09060 Protein ID WP_003408469.1
Coordinates 1940898..1941125 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS09020 1936142..1937056 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JN142_RS09025 1937059..1937889 + 831 WP_003906661.1 cyclase family protein -
JN142_RS09030 1937889..1938238 + 350 Protein_1782 cupin domain-containing protein -
JN142_RS09035 1938291..1939109 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JN142_RS09040 1939123..1939902 + 780 WP_003408460.1 IclR family transcriptional regulator -
JN142_RS09050 1940333..1940464 + 132 Protein_1785 IS3 family transposase -
JN142_RS09055 1940512..1940901 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS09060 1940898..1941125 - 228 WP_003408469.1 antitoxin Antitoxin
JN142_RS09065 1941343..1942827 + 1485 WP_009937637.1 biotin carboxylase -
JN142_RS09070 1942824..1944071 + 1248 WP_003408476.1 serine hydrolase -
JN142_RS09075 1944114..1944533 - 420 WP_003408483.1 hypothetical protein -
JN142_RS09080 1944523..1945233 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T189428 WP_003408465.1 NZ_CP069071:c1940901-1940512 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T189428 NZ_CP090765:c282645-282295 [Burkholderia multivorans]
ATGGTGAAGCGCGTCAAGTTCGAACGAGGCGATATCGTGCGCGTAAGCCTGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCCCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGCGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT189428 WP_003408469.1 NZ_CP069071:c1941125-1940898 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT189428 NZ_CP090765:c282890-282639 [Burkholderia multivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGTGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGGTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References