Detailed information of TA system TA189423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1389940..1390499
• Replicon: chromosome
• Accession: NZ_CP069071
• Organism: Mycobacterium tuberculosis strain N0136

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JN142_RS06635
• Protein ID: WP_003898789.1
• Coordinates: 1389940..1390233 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JN142_RS06640
• Protein ID: WP_003406322.1
• Coordinates: 1390230..1390499 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN142_RS06610	1385534..1385794	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JN142_RS06615	1385791..1386222	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JN142_RS06620	1386245..1387932	-	1688	Protein_1307	PE family protein	-
JN142_RS06625	1388112..1388972	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
JN142_RS06630	1389053..1389883	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JN142_RS06635	1389940..1390233	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JN142_RS06640	1390230..1390499	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN142_RS06645	1390612..1394307	-	3696	WP_009938349.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JN142_RS06650	1394449..1395237	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T189423 WP_003898789.1 NZ_CP069071:c1390233-1389940 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T189423 NZ_CP090764:c877811-877473 [Burkholderia cenocepacia]
ATGGTTTACACATTGCAATGCATGCCCTACAGTCCTCCTGCATTCGGCATCCGGACCACCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCCCGATCGCCTCGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTGTGCGGCGGAGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GTACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT189423 WP_003406322.1 NZ_CP069071:c1390499-1390230 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT189423 NZ_CP090764:c877469-877170 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCTCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGCCGCCAAGGCTGCCGCGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2