Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1024422..1025395 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag JN142_RS04865 Protein ID WP_003404756.1
Coordinates 1024895..1025395 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag JN142_RS04860 Protein ID WP_003898647.1
Coordinates 1024422..1024898 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS04840 1020269..1021540 - 1272 WP_003404747.1 PPE family protein -
JN142_RS04845 1021555..1021854 - 300 WP_003404748.1 PE family protein -
JN142_RS04850 1022298..1024079 + 1782 WP_003404749.1 BCCT family transporter -
JN142_RS04855 1024079..1024333 + 255 WP_003898646.1 hypothetical protein -
JN142_RS04860 1024422..1024898 + 477 WP_003898647.1 DUF1778 domain-containing protein Antitoxin
JN142_RS04865 1024895..1025395 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
JN142_RS04875 1025708..1027027 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
JN142_RS04880 1027315..1027896 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
JN142_RS04885 1027896..1029548 + 1653 WP_003404761.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1024076..1069982 45906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T189418 WP_003404756.1 NZ_CP069071:1024895-1025395 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T189418 NZ_CP090761:2245493-2245831 [Burkholderia cenocepacia]
ATGGTTTACACATTGCAATGCATGCCCTACAGTCCTCCTGCATTCGGCATCCGGACCACCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCCCGATCGCCTCGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTGTGCGGCGGAGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GTACCTCGACATGGAGTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT189418 WP_003898647.1 NZ_CP069071:1024422-1024898 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT189418 NZ_CP090761:2245835-2246134 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCTCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGCCGCCAAGGCTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB A5U0V8

References