Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 755133..755925 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN142_RS03485 Protein ID WP_003403386.1
Coordinates 755488..755925 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JN142_RS03480 Protein ID WP_003403381.1
Coordinates 755133..755378 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS03450 750153..751658 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN142_RS03455 751739..752749 + 1011 WP_009937374.1 ABC transporter ATP-binding protein -
JN142_RS03460 753137..753520 - 384 WP_003403365.1 ribonuclease VapC6 -
JN142_RS03465 753615..753770 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN142_RS03470 753846..754562 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN142_RS03475 754838..755146 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN142_RS03480 755133..755378 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
JN142_RS03485 755488..755925 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS03490 755922..756176 - 255 WP_003911263.1 antitoxin VapB7 -
JN142_RS03495 756290..758653 + 2364 WP_003898547.1 arylsulfatase AtsD -
JN142_RS03500 758716..759042 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN142_RS03505 758954..759292 + 339 WP_003403405.1 PIN domain-containing protein -
JN142_RS03510 759289..759462 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189414 WP_003403386.1 NZ_CP069071:c755925-755488 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189414 NZ_CP090761:c769375-768794 [Burkholderia cenocepacia]
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCTGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGATCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCAGCCACCTCGCCGGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAACAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT189414 WP_003403381.1 NZ_CP069071:c755378-755133 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT189414 NZ_CP090761:c770020-769454 [Burkholderia cenocepacia]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGATACCGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References