Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 702864..703507 Replicon chromosome
Accession NZ_CP069071
Organism Mycobacterium tuberculosis strain N0136

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN142_RS03190 Protein ID WP_003403187.1
Coordinates 703106..703507 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN142_RS03185 Protein ID WP_003403184.1
Coordinates 702864..703109 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN142_RS03150 698144..698674 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN142_RS03155 698658..699353 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN142_RS03160 699476..699787 + 312 WP_003403164.1 hypothetical protein -
JN142_RS03165 699859..700809 + 951 WP_003900184.1 DUF1259 domain-containing protein -
JN142_RS03170 701050..701634 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN142_RS03175 701636..702346 + 711 Protein_629 IS607 family element RNA-guided endonuclease TnpB -
JN142_RS03180 702349..702819 + 471 WP_003898523.1 hypothetical protein -
JN142_RS03185 702864..703109 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN142_RS03190 703106..703507 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN142_RS03195 703498..703677 + 180 Protein_633 hypothetical protein -
JN142_RS03200 704095..704292 - 198 WP_003403191.1 hypothetical protein -
JN142_RS03205 704372..705529 - 1158 WP_003898524.1 hypothetical protein -
JN142_RS03210 705581..705802 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN142_RS03215 705944..706549 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189408 WP_003403187.1 NZ_CP069071:703106-703507 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189408 NZ_CP090758:c1227462-1227163 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGTCTTACACGTACAA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189408 WP_003403184.1 NZ_CP069071:702864-703109 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189408 NZ_CP090758:c1227697-1227452 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGACCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCTCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References