Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3784781..3785310 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN143_RS17780 Protein ID WP_003417760.1
Coordinates 3785053..3785310 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN143_RS17775 Protein ID WP_003417757.1
Coordinates 3784781..3785056 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS17740 3781354..3782043 - 690 WP_003917774.1 BBE domain-containing protein -
JN143_RS17745 3782230..3782601 - 372 WP_003417739.1 FAD-binding protein -
JN143_RS17750 3782499..3782717 - 219 WP_157132559.1 hypothetical protein -
JN143_RS17755 3782744..3783004 - 261 WP_003417741.1 hypothetical protein -
JN143_RS17760 3783119..3783508 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN143_RS17765 3783522..3783815 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN143_RS17770 3783812..3784657 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN143_RS17775 3784781..3785056 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN143_RS17780 3785053..3785310 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN143_RS17785 3785352..3786542 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN143_RS17790 3786659..3787027 + 369 WP_003417765.1 FHA domain-containing protein -
JN143_RS17795 3787024..3787575 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JN143_RS17800 3787582..3788163 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN143_RS17805 3788144..3788512 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN143_RS17810 3788490..3788882 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T189396 WP_003417760.1 NZ_CP069070:3785053-3785310 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T189396 NZ_CP090754:901168-902064 [Burkholderia multivorans]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCAGGCTGGCGCCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCATCGCCGTCGGCCGTCGATTATGCGGCGTCGCTCGACGC
GTGGCTCGACGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGGATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGCGCGCCGGCCGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAGGACGCGCGCGCATGGGTGCGCTGGAATATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCGGCCGATCTCGCCGGGTTCCGCGGCCGCACGGCGGTGGCCGTGGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGCGAACGCATCGCGGCGGCCGCCGGCGTCGGACTGCAGGTGATTCCGCA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCCGACGTCTATTCGGCCTTGATCGACGCGTTCTGCCGGCAGTGCGACATCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT189396 WP_003417757.1 NZ_CP069070:3784781-3785056 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT189396 NZ_CP090754:902061-902915 [Burkholderia multivorans]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAACCTGCGAAGGCCGAAGCGAGCTACGTCGTGCCCGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTTGCGAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTGTCGCTGGACGAGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGACGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGGATTTCGGTCGTGACCGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGACGGGCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAACACACGTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References