Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3719203..3719877 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN143_RS17570 Protein ID WP_003417282.1
Coordinates 3719203..3719631 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN143_RS17575 Protein ID WP_003417286.1
Coordinates 3719635..3719877 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS17545 3715025..3715426 - 402 WP_003417264.1 cytidine deaminase -
JN143_RS17550 3715663..3716001 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN143_RS17555 3715998..3716432 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN143_RS17560 3716561..3718333 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN143_RS17565 3718333..3719124 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN143_RS17570 3719203..3719631 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN143_RS17575 3719635..3719877 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN143_RS17580 3719999..3720613 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN143_RS17585 3720610..3721275 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN143_RS17590 3721276..3721809 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN143_RS17595 3721806..3722180 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN143_RS17600 3722277..3723281 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189395 WP_003417282.1 NZ_CP069070:c3719631-3719203 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189395 NZ_CP090754:791406-791825 [Burkholderia multivorans]
ATGATCCTTGTCGATACGAACGTCATTTCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCCTCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189395 WP_003417286.1 NZ_CP069070:c3719877-3719635 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189395 NZ_CP090754:791170-791409 [Burkholderia multivorans]
ATGCCTGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCCAACCGATCCGATCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References