Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3143224..3144998 | Replicon | chromosome |
| Accession | NZ_CP069070 | ||
| Organism | Mycobacterium tuberculosis strain N1283 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | JN143_RS14945 | Protein ID | WP_003414409.1 |
| Coordinates | 3143224..3144108 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | JN143_RS14950 | Protein ID | WP_003414414.1 |
| Coordinates | 3144111..3144998 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN143_RS14925 | 3138479..3138853 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| JN143_RS14930 | 3138850..3141288 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| JN143_RS14935 | 3141285..3142073 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| JN143_RS14940 | 3142407..3142952 | - | 546 | WP_003913758.1 | DUF1802 family protein | - |
| JN143_RS14945 | 3143224..3144108 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JN143_RS14950 | 3144111..3144998 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JN143_RS14955 | 3145303..3145848 | - | 546 | WP_031717009.1 | DUF1802 family protein | - |
| JN143_RS14960 | 3145845..3146114 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| JN143_RS14965 | 3146135..3146527 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN143_RS14970 | 3146524..3146739 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN143_RS14975 | 3146786..3147535 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| JN143_RS14980 | 3147614..3148696 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T189390 WP_003414409.1 NZ_CP069070:c3144108-3143224 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T189390 NZ_CP090752:9652-9921 [Burkholderia multivorans]
ATGGCCTACCGGATTGAGATCGATCCGGCAGCGGAAAGGGAACTGGACAAGCTGGACAGAGAAATCGCAAAACGCATCCT
CCGATTCCTCTTCGAGCGGGTTGCCAAGCTGGACGACCCGCGAAGCATCGGAGAGGCGTTGAAGGGCTCCAAGCTGGGCG
AATTCTGGAAATATCGCGTCGGCGACTATCGCATCATTGCCGACATTCAAGACGGCGTGCTGTGCATTCTCGTCTTGCGG
GTTGGCAACCGCCGGGAGGTCTACCGATGA
ATGGCCTACCGGATTGAGATCGATCCGGCAGCGGAAAGGGAACTGGACAAGCTGGACAGAGAAATCGCAAAACGCATCCT
CCGATTCCTCTTCGAGCGGGTTGCCAAGCTGGACGACCCGCGAAGCATCGGAGAGGCGTTGAAGGGCTCCAAGCTGGGCG
AATTCTGGAAATATCGCGTCGGCGACTATCGCATCATTGCCGACATTCAAGACGGCGTGCTGTGCATTCTCGTCTTGCGG
GTTGGCAACCGCCGGGAGGTCTACCGATGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT189390 WP_003414414.1 NZ_CP069070:c3144998-3144111 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT189390 NZ_CP090752:9444-9668 [Burkholderia multivorans]
ATGCTTGCGATCCGTCTGCCCCCGGAAGTCGAAAGCCGCCTCGATGCGTTGGCGGCCGCTACCGGGCGCACCAAGACTTT
CCTAGCCCGCGAGGCCATCCTCGACAATCTGGACAGACTGGAGGACGTGTACCTGGCTGAGCAGCGCCTGGTCGATATCC
GCGCCGGTCGTACAGAGCCCATTCCCCTTGAAGACGTCATGAAGAAATATGGCCTACCGGATTGA
ATGCTTGCGATCCGTCTGCCCCCGGAAGTCGAAAGCCGCCTCGATGCGTTGGCGGCCGCTACCGGGCGCACCAAGACTTT
CCTAGCCCGCGAGGCCATCCTCGACAATCTGGACAGACTGGAGGACGTGTACCTGGCTGAGCAGCGCCTGGTCGATATCC
GCGCCGGTCGTACAGAGCCCATTCCCCTTGAAGACGTCATGAAGAAATATGGCCTACCGGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|