Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2474121..2474665 | Replicon | chromosome |
| Accession | NZ_CP069070 | ||
| Organism | Mycobacterium tuberculosis strain N1283 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN143_RS11650 | Protein ID | WP_003409896.1 |
| Coordinates | 2474369..2474665 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN143_RS11645 | Protein ID | WP_003409899.1 |
| Coordinates | 2474121..2474372 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN143_RS11620 | 2469848..2470645 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
| JN143_RS11625 | 2471544..2472764 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN143_RS11630 | 2472797..2473069 | + | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN143_RS11635 | 2473073..2473480 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN143_RS11640 | 2473640..2474134 | - | 495 | WP_003899099.1 | hypothetical protein | - |
| JN143_RS11645 | 2474121..2474372 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN143_RS11650 | 2474369..2474665 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN143_RS11655 | 2474714..2475328 | + | 615 | WP_003901296.1 | hypothetical protein | - |
| JN143_RS11660 | 2475217..2475762 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN143_RS11665 | 2475759..2476208 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN143_RS11670 | 2476250..2476627 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN143_RS11675 | 2476602..2477123 | + | 522 | WP_003904745.1 | hypothetical protein | - |
| JN143_RS11680 | 2477097..2477408 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN143_RS11685 | 2477405..2477620 | - | 216 | WP_003409878.1 | antitoxin | - |
| JN143_RS11690 | 2477860..2478156 | + | 297 | WP_003409877.1 | hypothetical protein | - |
| JN143_RS11695 | 2478157..2478348 | + | 192 | WP_003409876.1 | hypothetical protein | - |
| JN143_RS11700 | 2478369..2479271 | + | 903 | WP_003899097.1 | hypothetical protein | - |
| JN143_RS11705 | 2479282..2479632 | + | 351 | WP_003899096.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189380 WP_003409896.1 NZ_CP069070:2474369-2474665 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189380 NZ_CP069070:2474369-2474665 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACTTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACTTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189380 WP_003409899.1 NZ_CP069070:2474121-2474372 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189380 NZ_CP069070:2474121-2474372 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |