Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 844021..844730 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag JN143_RS03975 Protein ID WP_003403837.1
Coordinates 844302..844730 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag JN143_RS03970 Protein ID WP_003403834.1
Coordinates 844021..844278 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS03965 841527..843930 + 2404 Protein_784 PE family protein -
JN143_RS03970 844021..844278 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
JN143_RS03975 844302..844730 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
JN143_RS03980 844811..844948 - 138 WP_003403839.1 hypothetical protein -
JN143_RS03990 845107..845352 + 246 WP_003403841.1 hypothetical protein -
JN143_RS03995 845421..846305 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
JN143_RS04000 846316..847488 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
JN143_RS04005 847495..849027 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T189355 WP_003403837.1 NZ_CP069070:844302-844730 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T189355 NZ_CP090740:c1030997-1030638 [Burkholderia multivorans]
ATGGTTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGGACTTGAAAGCGATGCCCGAAGCGGTACAGGA
CACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGTTGAGGGGTTTCGGATCGG
CCGGCGTACTCGAGGTCGTGGAGTCGGAGGACAGCGGCACCTACCGGGCGGTCTATACGGTGAAACTCGGTGGCGCCGTC
TATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACATCGAACTGGTTCGCGCGCG
CCTGAGCGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT189355 WP_003403834.1 NZ_CP069070:844021-844278 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT189355 NZ_CP090740:c1030638-1030315 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGGAACGTCTACGCGGATCTTGGCACGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATTGCGGAGATCATCAAGACTCGCAAATGGACGCAGCAGCACGCAGCACGATTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References