Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 758007..758799 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN143_RS03500 Protein ID WP_003403386.1
Coordinates 758362..758799 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JN143_RS03495 Protein ID WP_003403381.1
Coordinates 758007..758252 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS03465 753026..754532 + 1507 Protein_684 carotenoid cleavage oxygenase -
JN143_RS03470 754613..755623 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN143_RS03475 756011..756394 - 384 WP_003403365.1 ribonuclease VapC6 -
JN143_RS03480 756489..756644 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin -
JN143_RS03485 756720..757436 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN143_RS03490 757712..758020 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN143_RS03495 758007..758252 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
JN143_RS03500 758362..758799 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN143_RS03505 758796..759050 - 255 WP_003911263.1 antitoxin VapB7 -
JN143_RS03510 759164..761527 + 2364 WP_031582834.1 arylsulfatase AtsD -
JN143_RS03515 761590..761916 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN143_RS03520 761828..762166 + 339 WP_003403405.1 PIN domain-containing protein -
JN143_RS03525 762163..762336 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189353 WP_003403386.1 NZ_CP069070:c758799-758362 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189353 NZ_CP090738:2664877-2665194 [Burkholderia cepacia]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACGCATGGTTTGCCGGCCTGCGGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCGGGCTCGCCGG
TCGTCGAAATGCGGATCGACCACGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT189353 WP_003403381.1 NZ_CP069070:c758252-758007 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT189353 NZ_CP090738:2665198-2665497 [Burkholderia cepacia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACC
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCAAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References