Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 756011..756644 Replicon chromosome
Accession NZ_CP069070
Organism Mycobacterium tuberculosis strain N1283

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN143_RS03475 Protein ID WP_003403365.1
Coordinates 756011..756394 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A655G1G4
Locus tag JN143_RS03480 Protein ID WP_031582830.1
Coordinates 756489..756644 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN143_RS03450 751302..751838 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN143_RS03455 751875..752267 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN143_RS03460 752260..752955 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN143_RS03465 753026..754532 + 1507 Protein_684 carotenoid cleavage oxygenase -
JN143_RS03470 754613..755623 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN143_RS03475 756011..756394 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN143_RS03480 756489..756644 - 156 WP_031582830.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN143_RS03485 756720..757436 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN143_RS03490 757712..758020 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN143_RS03495 758007..758252 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN143_RS03500 758362..758799 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN143_RS03505 758796..759050 - 255 WP_003911263.1 antitoxin VapB7 -
JN143_RS03510 759164..761527 + 2364 WP_031582834.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T189351 WP_003403365.1 NZ_CP069070:c756394-756011 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T189351 NZ_CP090738:2241070-2241435 [Burkholderia cepacia]
ATGGTAAAAGCCCTGTTCGACACCAACATCCTGATCGACTACCTGGGCGGCGTGGAATCGGCCCGCGTCGAACTGGCCCG
CTACTCCTATCGTGCGATCAGCATCATCTCGTGGATGGAGGTTCTTGTCGGCACGTCCGCACATGACGAAAACACGACTC
GCGCGTGGCTCTCGTCATTCGATGTCATCGCGCTCGACAGCACGATTGCGAATCGCGCCGTGACCATTCGCCAGGAGCGC
CGCATCCGCCTGCCCGACGCGATCGTCTGGGCATCGGCGCAAGTCAACGGCCTGCTGCTTGTGTCGCGCAACACAAAGGA
CTTCCCCGCCACCGAACCCGGCATTCGAATGCCGTATCGGATCTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5860.66 Da        Isoelectric Point: 5.7734

>AT189351 WP_031582830.1 NZ_CP069070:c756644-756489 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRTAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT189351 NZ_CP090738:2240858-2241076 [Burkholderia cepacia]
ATGAGCCGGATTCTGGTGGATCTGTCAGATGGCCAGCTCGACGAGTTGGCCGCCATCGTCGAGACTGAACGTCGTCCCCG
CGCCGCGATCATTCGCGACGCGATTGATGCCTACATTGCCCTGCACAAACGCCCGCTCGCCGACGACGCATTCGGTCTCT
GGAAAGATCGCACGGTCGACGGCCTGGCGTATCAGGAGGAAATGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A655G1G4

References