Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
| Location | 699647..700293 | Replicon | chromosome |
| Accession | NZ_CP069070 | ||
| Organism | Mycobacterium tuberculosis strain N1283 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ88 |
| Locus tag | JN143_RS03150 | Protein ID | WP_003403137.1 |
| Coordinates | 699647..700060 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ89 |
| Locus tag | JN143_RS03155 | Protein ID | WP_003403139.1 |
| Coordinates | 700057..700293 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN143_RS03130 | 695730..697280 | + | 1551 | WP_003403119.1 | MlaD family protein | - |
| JN143_RS03135 | 697332..697724 | - | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
| JN143_RS03140 | 697721..697978 | - | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
| JN143_RS03145 | 698161..699396 | - | 1236 | WP_003403128.1 | ATP-binding protein | - |
| JN143_RS03150 | 699647..700060 | - | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JN143_RS03155 | 700057..700293 | - | 237 | WP_003403139.1 | type II toxin-antitoxin system antitoxin VapB27 | Antitoxin |
| JN143_RS03160 | 700397..700903 | - | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
| JN143_RS03165 | 701017..701547 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
| JN143_RS03170 | 701531..702226 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
| JN143_RS03175 | 702349..702660 | + | 312 | WP_003403164.1 | hypothetical protein | - |
| JN143_RS03180 | 702732..703682 | + | 951 | WP_003900184.1 | DUF1259 domain-containing protein | - |
| JN143_RS03185 | 703923..704507 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
| JN143_RS03190 | 704509..705219 | + | 711 | Protein_632 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T189346 WP_003403137.1 NZ_CP069070:c700060-699647 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
>T189346 NZ_CP090738:c860768-860187 [Burkholderia cepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCGCAGCGCGACGAGATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCCGCAATCCGCCCGGTTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGAGCGGGCAGCACGCGTAA
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCGCAGCGCGACGAGATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCCGCAATCCGCCCGGTTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGAGCGGGCAGCACGCGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8212.41 Da Isoelectric Point: 5.0351
>AT189346 WP_003403139.1 NZ_CP069070:c700293-700057 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
Download Length: 237 bp
>AT189346 NZ_CP090738:c861408-860851 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACACGCCGCCACTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAACAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAGTCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCACGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCTGTTCGCCTGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCCGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGTCGGCCGCGCGGCTCGTGGAAACGCTGTAG
ATGTCTGCCTCACCGCTACACACGCCGCCACTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAACAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAGTCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCACGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCTGTTCGCCTGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCCGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGTCGGCCGCGCGGCTCGTGGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|