Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3720780..3721454 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN144_RS17630 Protein ID WP_003417282.1
Coordinates 3720780..3721208 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN144_RS17635 Protein ID WP_003417286.1
Coordinates 3721212..3721454 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS17605 3716602..3717003 - 402 WP_003417264.1 cytidine deaminase -
JN144_RS17610 3717240..3717578 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN144_RS17615 3717575..3718009 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN144_RS17620 3718138..3719910 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN144_RS17625 3719910..3720701 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN144_RS17630 3720780..3721208 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS17635 3721212..3721454 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN144_RS17640 3721576..3722190 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN144_RS17645 3722187..3722852 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN144_RS17650 3722853..3723386 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN144_RS17655 3723383..3723757 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN144_RS17660 3723854..3724858 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189334 WP_003417282.1 NZ_CP069069:c3721208-3720780 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189334 NZ_CP090735:c234537-234187 [Burkholderia multivorans]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCACCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189334 WP_003417286.1 NZ_CP069069:c3721454-3721212 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189334 NZ_CP090735:c234782-234531 [Burkholderia multivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References