Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3146315..3148089 | Replicon | chromosome |
| Accession | NZ_CP069069 | ||
| Organism | Mycobacterium tuberculosis strain N1176 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | JN144_RS15000 | Protein ID | WP_003414409.1 |
| Coordinates | 3146315..3147199 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | JN144_RS15005 | Protein ID | WP_003414414.1 |
| Coordinates | 3147202..3148089 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN144_RS14980 | 3141570..3141944 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| JN144_RS14985 | 3141941..3144379 | - | 2439 | WP_031667895.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| JN144_RS14990 | 3144376..3145164 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| JN144_RS14995 | 3145498..3146043 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
| JN144_RS15000 | 3146315..3147199 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JN144_RS15005 | 3147202..3148089 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JN144_RS15010 | 3148394..3148939 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| JN144_RS15015 | 3148936..3149205 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| JN144_RS15020 | 3149226..3149618 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN144_RS15025 | 3149615..3149830 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN144_RS15030 | 3149877..3150626 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| JN144_RS15035 | 3150705..3151787 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T189329 WP_003414409.1 NZ_CP069069:c3147199-3146315 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T189329 NZ_CP090732:2676511-2676810 [Burkholderia cepacia]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACC
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCAAAAGCGCACGCATGA
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGACCATCTGAAGACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCACGCGCTCGGCGTGATCGCACGCGCACGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACC
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCAAAAGCGCACGCATGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT189329 WP_003414414.1 NZ_CP069069:c3148089-3147202 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT189329 NZ_CP090732:2676190-2676507 [Burkholderia cepacia]
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACGCATGGTTTGCCGGCCTGCGGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCGGGCTCGCCGG
TCGTCGAAATGCGGATCGACCACGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA
ATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACGCATGGTTTGCCGGCCTGCGGGATCGCGT
CGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCGGGCTCGCCGG
TCGTCGAAATGCGGATCGACCACGGCCCCGGTTATCGCGTCTACTACGTCCGGCGCGGAACGATCTGGGTCATCCTGCTC
TGCGGCGGCGATAAATCGACGCAACAGGCCGACATACGCGCCGCGCACGCGATGCTCGCGCACCTCGACATGGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|