Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2820137..2820789 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN144_RS13250 Protein ID WP_003412752.1
Coordinates 2820364..2820789 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U8TSR0
Locus tag JN144_RS13245 Protein ID WP_003909675.1
Coordinates 2820137..2820358 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS13230 2818377..2818583 - 207 WP_003899347.1 hypothetical protein -
JN144_RS13235 2818719..2819342 + 624 WP_003900858.1 TIGR00725 family protein -
JN144_RS13240 2819332..2820084 + 753 WP_003901416.1 hypothetical protein -
JN144_RS13245 2820137..2820358 + 222 WP_003909675.1 hypothetical protein Antitoxin
JN144_RS13250 2820364..2820789 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS13255 2820812..2821993 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN144_RS13260 2821990..2823036 - 1047 WP_003909676.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN144_RS13265 2823047..2824150 - 1104 WP_003909677.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN144_RS13270 2824409..2825230 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN144_RS13275 2825227..2825784 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189319 WP_003412752.1 NZ_CP069069:2820364-2820789 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189319 NZ_CP090732:185253-185534 [Burkholderia cepacia]
ATGACCTTTGAACTTGCCTTTCTCGAACCTGCATTGAAGGAGTGGAAGAAGCTCGATCGCACCGTGCGCGATCAATTCAA
GGCCAAGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCCGGATCGCTACAAGATCA
AGCTGCGTGGTGTCGGGTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGGTGGTCGCGGTCGGCCGC
CGCGAGCGTGATGCGGTTTATCTGGCTGCGATGAAACGCTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7863.99 Da        Isoelectric Point: 5.0323

>AT189319 WP_003909675.1 NZ_CP069069:2820137-2820358 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDKD

Download         Length: 222 bp

>AT189319 NZ_CP090732:185015-185263 [Burkholderia cepacia]
ATGCCTCACACCATTCTGGCGAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCAGG
TGAAGGTTTTCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTACTGCATTCCCGCGAAGACGTGGGAGGCGATGG
TCGAACGTTTGGAAGACATCGAAGACAATGCGTTGGCCGATTCGCGCGCCAGGGAGAAGGTCGTCAAGGTTAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8TSR0

References