Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2417407..2417936 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN144_RS11355 Protein ID WP_003411124.1
Coordinates 2417407..2417724 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN144_RS11360 Protein ID WP_003411127.1
Coordinates 2417721..2417936 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS11325 2412428..2413504 + 1077 WP_003411110.1 hypothetical protein -
JN144_RS11330 2413501..2413782 + 282 WP_003411112.1 DUF5703 family protein -
JN144_RS11335 2413818..2414891 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN144_RS11340 2414896..2415426 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN144_RS11345 2415474..2416820 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN144_RS11355 2417407..2417724 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN144_RS11360 2417721..2417936 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN144_RS11365 2418191..2419249 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN144_RS11370 2419379..2419735 - 357 WP_003411130.1 hypothetical protein -
JN144_RS11375 2419830..2420612 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN144_RS11380 2420880..2421170 - 291 WP_003900476.1 YggT family protein -
JN144_RS11385 2421332..2421988 - 657 WP_003411133.1 cell division protein SepF -
JN144_RS11390 2422054..2422830 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189318 WP_003411124.1 NZ_CP069069:c2417724-2417407 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189318 NZ_CP090730:c2254014-2253598 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCCGATCTCGCCGCGCGCGGCATGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGAACAACGGGCGGGAGTTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCAGCCTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189318 WP_003411127.1 NZ_CP069069:c2417936-2417721 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189318 NZ_CP090730:c2254271-2254011 [Burkholderia cepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGTCGCGAGGGCGACACGCTGCTGCTGCGGCCCGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References