Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2380603..2381298 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN144_RS11150 Protein ID WP_003410811.1
Coordinates 2380603..2381037 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN144_RS11155 Protein ID WP_003410814.1
Coordinates 2381044..2381298 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS11140 2376757..2379798 + 3042 WP_031667498.1 DEAD/DEAH box helicase -
JN144_RS11145 2379791..2380624 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN144_RS11150 2380603..2381037 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS11155 2381044..2381298 - 255 WP_003410814.1 antitoxin Antitoxin
JN144_RS11160 2381314..2381571 - 258 WP_003410816.1 hypothetical protein -
JN144_RS11165 2382518..2382814 + 297 WP_003410820.1 PE family protein -
JN144_RS11170 2382870..2383601 + 732 WP_003900467.1 PPE family protein -
JN144_RS11175 2384141..2384887 - 747 WP_003901330.1 proteasome subunit alpha -
JN144_RS11180 2384884..2385759 - 876 WP_003411023.1 proteasome subunit beta -
JN144_RS11185 2385756..2385950 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189317 WP_003410811.1 NZ_CP069069:c2381037-2380603 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189317 NZ_CP090730:c1350563-1350201 [Burkholderia cepacia]
ATGGATCCGTACATCAAACCGCTGTACTGGCTCGGTTCGGCGCTTAAGGACCTGAAAGCGATGCCCGATGCCGTACAGGA
CACGGTCGGATATGCGCTGTACCTGGCGCAGACGGGACGAAAGCACGATCACGCCAAGCCGTTGAGGGGCTTCGGATCGG
CCGGCGTGCTCGAGATCGTGGAATCGGAAGACAACGGCACGTACCGCGCCGTCTACACCGTGAAGCTCGGGAACAGCGTG
TACGTGCTGCACAGCTTCCAGAAAAAATCGTCGAGCGGCATCGCGACACCGAAGCCGGACGTCGATCTGATCCGTGAACG
CCTGAAAGCAGCCGAAGCACACGCAAAAGGAGAAAGTCGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189317 WP_003410814.1 NZ_CP069069:c2381298-2381044 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189317 NZ_CP090730:c1350204-1349881 [Burkholderia cepacia]
ATGATCGAAATCGAGCAGGGCAGCGGTAACGTCTACGCCGATCTGGGTAGGCACGATGCCGACGAAATGCTTGTGAAGGC
GCAACTCGCCGCCAAGATCGCCGAGATCATCAAGGCGCGCAAATGGACGCAGCAGCATGCCGCGCGATTGCTCGGCATGA
CGCAACCGAAACTGTCGAACATGCTGCGCGGACAGTTTCGCGGCGTGAGCGAAACGAAGATGATCGAGTGTCTGGCGAAG
CTCGGGCGCGACGTGCAGATCGTCGTCGGACCCGACCGTCATTCGGAAATCGAGGGGCACATCGAAGTCGTATTCGCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References