Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2239691..2240379 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN144_RS10510 Protein ID WP_003409958.1
Coordinates 2239691..2240110 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN144_RS10515 Protein ID WP_003409968.1
Coordinates 2240119..2240379 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS10485 2235041..2235319 - 279 WP_003907828.1 hypothetical protein -
JN144_RS10490 2235449..2236096 - 648 WP_003909553.1 PE family protein -
JN144_RS10495 2236876..2237475 + 600 WP_234776458.1 hypothetical protein -
JN144_RS10500 2237621..2238307 - 687 WP_003909555.1 immunoprotective protein Mpt64 -
JN144_RS10505 2238498..2239466 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN144_RS10510 2239691..2240110 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS10515 2240119..2240379 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN144_RS10520 2240522..2242198 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN144_RS10525 2242186..2242839 - 654 WP_003409976.1 cutinase Cfp21 -
JN144_RS10530 2242954..2243184 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN144_RS10535 2243269..2244180 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN144_RS10540 2244289..2244888 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189311 WP_003409958.1 NZ_CP069069:c2240110-2239691 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189311 NZ_CP090727:c1656787-1656368 [Burkholderia multivorans]
ATGATCCTTGTCGATACGAACGTCATTTCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCCTCATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189311 WP_003409968.1 NZ_CP069069:c2240379-2240119 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189311 NZ_CP090727:c1657023-1656784 [Burkholderia multivorans]
ATGCCTGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCCAACCGATCCGATCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References