Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 757182..757870 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN144_RS03520 Protein ID WP_003403386.1
Coordinates 757182..757619 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag JN144_RS03525 Protein ID WP_003911263.1
Coordinates 757616..757870 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS03490 753433..754443 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN144_RS03495 754831..755214 - 384 WP_003403365.1 ribonuclease VapC6 -
JN144_RS03500 755309..755464 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN144_RS03505 755540..756256 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN144_RS03510 756532..756840 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN144_RS03515 756827..757072 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN144_RS03520 757182..757619 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS03525 757616..757870 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
JN144_RS03530 757984..760348 + 2365 Protein_697 arylsulfatase AtsD -
JN144_RS03535 760411..760737 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN144_RS03540 760649..760987 + 339 WP_003403405.1 PIN domain-containing protein -
JN144_RS03545 760984..761157 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189293 WP_003403386.1 NZ_CP069069:c757619-757182 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189293 NZ_CP090722:1509530-1509895 [Burkholderia multivorans]
ATGGTAAAAGCCCTCTTCGACACCAACATCCTGATCGACTATCTGAGCGGCGTGGAGTCGGCCCGCCTGGAGCTCGGCCG
CTACGACCACCGTGCAATCAGCACCATTACGTGGATGGAAGTCCTGGTCGGTACGACCGCAGATGACGAAGGCCCGATTC
GCGCGTGGCTCTCGTCGTTCGACGTGATCCCGCTCGACATTACGGTTGCCGACCGCGCCGTGACCATTCGCAAGGAACGG
CGCATTCGTCTGCCCGACGCGATCGTCTGGGCATCAGCGCAGGTGAACGGACGCCTGCTCGTGTCGCGCAACACGAAAGA
CTTTCCCTCGACGGAACCCGGCATCCGGGTGCCTTACCAGATCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT189293 WP_003911263.1 NZ_CP069069:c757870-757616 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT189293 NZ_CP090722:1509318-1509536 [Burkholderia multivorans]
ATGAGCCGAGTCTTGGTGGATCTGTCGGACGGCCAGCTCGACGAGCTGGCCGTCATCGTCGAGACTGAGCATCGTCCTCG
CGCCGCGATCATTCGCGATGCGATTGACGCCTACATCGCCCTACACAAGCGCCCGCTCGCCGACGATGTCTTCGGCCTCT
GGAAAGACCGCGCCGTCGACGGGCTCGCTTATCAGGAAAAACTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References