Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712095..712720 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN144_RS03275 Protein ID WP_003403218.1
Coordinates 712319..712720 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN144_RS03270 Protein ID WP_003403213.1
Coordinates 712095..712322 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS03245 707274..707495 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN144_RS03250 707637..708242 + 606 WP_003898526.1 hypothetical protein -
JN144_RS03255 708261..710828 - 2568 WP_003909263.1 SEC-C metal-binding domain-containing protein -
JN144_RS03260 710912..711661 + 750 WP_003898528.1 hypothetical protein -
JN144_RS03265 711658..711900 + 243 WP_003403210.1 hypothetical protein -
JN144_RS03270 712095..712322 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN144_RS03275 712319..712720 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN144_RS03280 712849..712932 + 84 Protein_650 galactose-1-phosphate uridylyltransferase -
JN144_RS03285 712951..714033 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN144_RS03290 714030..715121 + 1092 WP_003900977.1 galactokinase -
JN144_RS03295 715516..716673 + 1158 WP_003903091.1 hypothetical protein -
JN144_RS03300 716684..717631 + 948 WP_003909264.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T189287 WP_003403218.1 NZ_CP069069:712319-712720 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T189287 NZ_CP090720:c125728-125321 [Burkholderia multivorans]
ATGAGCCTCTATCTGCTCGACACCAATATTTTGTCGAACGTGATCCGAGACCCACGGGGCGCATGCGCTTCGCGCATCGG
GGAAACGCGGCCCGAGCAAGTGTGCACCTCGATCGTCGTCGCGGCCGAGCTACGGTACGGCGTCTGTAAGCGCGGCTCCT
CGGCGCTCGCCCAGCGTGTCGAGCAGCTGCTCGCGAGCTTGACCGTATTACCGCTGCAGTCCGACGCGGATCAGTGCTAC
GGGCGGCTGCGAGCCGATCTCGAGAGGCAGGGTCAGTTGATCGGGGCGAACGACATGCTGATCGCTGCCCACGCGATGGC
CGTCGACGCCGTCTTGGTCACGGACAATACGGCCGAATTCACTCGCGTTACAGGACTCGCCGTCGAAAACTGGCTCCGGC
CTGCGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT189287 WP_003403213.1 NZ_CP069069:712095-712322 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT189287 NZ_CP090720:c125967-125725 [Burkholderia multivorans]
ATGCCAACCCATGACACCCGCCACGCACGCCTATTTCGCAACGGACGTAGCCAGGCCGTGCGGATCCCGCGCGAGTTCGA
GCTGCCGGTCTCGGAAGTCACTATTCATCGTGAAGGCCGGCGCCTAATCATCGAACCGGTCGAAGCGCCGTCTCTACGCG
AGCTATTTGCGCAATGGGCGCCCTTGGACGAAACTTTCCCTGACATCGAAAACCTCCCCGCTGAACCGGTCGATATTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References