Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704557..705200 Replicon chromosome
Accession NZ_CP069069
Organism Mycobacterium tuberculosis strain N1176

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN144_RS03225 Protein ID WP_003403187.1
Coordinates 704799..705200 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN144_RS03220 Protein ID WP_003403184.1
Coordinates 704557..704802 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN144_RS03185 699833..700363 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN144_RS03190 700347..701042 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN144_RS03195 701165..701476 + 312 WP_003403164.1 hypothetical protein -
JN144_RS03200 701548..702501 + 954 WP_031667544.1 DUF1259 domain-containing protein -
JN144_RS03205 702742..703326 + 585 WP_031667543.1 IS607-like element IS1536 family transposase -
JN144_RS03210 703328..704039 + 712 Protein_636 IS607 family element RNA-guided endonuclease TnpB -
JN144_RS03215 704042..704512 + 471 WP_003898523.1 hypothetical protein -
JN144_RS03220 704557..704802 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN144_RS03225 704799..705200 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN144_RS03230 705191..705370 + 180 Protein_640 hypothetical protein -
JN144_RS03235 705788..705985 - 198 WP_003403191.1 hypothetical protein -
JN144_RS03240 706065..707222 - 1158 WP_003403193.1 hypothetical protein -
JN144_RS03245 707274..707495 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN144_RS03250 707637..708242 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189286 WP_003403187.1 NZ_CP069069:704799-705200 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189286 NZ_CP090718:1960166-1960450 [Burkholderia multivorans]
ATGACCAACTACACCGAGTTCGATGCGGCCGATTACCTCGACAACGATGAGGCGGTCGCGGAATTCCTCGCCGTCGCGGC
AGAGGACCCGAATCCTGACGTGTTCCTCGCGGCCGTCGCTGCGGTCGCGCGGGCGCGCGGTATGACGAAAGTTGCGGCAG
CCGCCGGCGTCGGCCGCGTCGCGCTTCACAAGGCACTGACGCCCGGCGCGCACCCGCGCTACGAAACCGTGCAGAAAATC
ATCCGGTCGCTCGGCCTGCGCATGAGCTTCAAGGTCGCGCACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189286 WP_003403184.1 NZ_CP069069:704557-704802 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189286 NZ_CP090718:1959992-1960162 [Burkholderia multivorans]
GTGCTCGACGAAGGGGTCTGCGAACTCAAGATCGACTTTGGTCCGGGCTACCGCGTGTATTACGTTCGACGCGGCGAAGT
GGTCTACCTCCTTCTGTGCGGCGGCGACAAGTCAACGCAACGGAAGGACGTCAAGCGCGCCGTGCAGATGGCGCGCGAAC
TGAAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References