Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3781519..3782048 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN145_RS17805 Protein ID WP_003417760.1
Coordinates 3781791..3782048 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN145_RS17800 Protein ID WP_003417757.1
Coordinates 3781519..3781794 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS17765 3778092..3778781 - 690 WP_003917774.1 BBE domain-containing protein -
JN145_RS17770 3778968..3779339 - 372 WP_003417739.1 FAD-binding protein -
JN145_RS17775 3779237..3779455 - 219 WP_157132559.1 hypothetical protein -
JN145_RS17780 3779482..3779742 - 261 WP_003417741.1 hypothetical protein -
JN145_RS17785 3779857..3780246 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN145_RS17790 3780260..3780553 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN145_RS17795 3780550..3781395 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN145_RS17800 3781519..3781794 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN145_RS17805 3781791..3782048 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN145_RS17810 3782090..3783280 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN145_RS17815 3783397..3783765 + 369 WP_003417765.1 FHA domain-containing protein -
JN145_RS17820 3783762..3784313 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JN145_RS17825 3784320..3784901 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN145_RS17830 3784882..3785250 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN145_RS17835 3785228..3785620 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T189274 WP_003417760.1 NZ_CP069068:3781791-3782048 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T189274 NZ_CP090715:2005122-2005439 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT189274 WP_003417757.1 NZ_CP069068:3781519-3781794 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT189274 NZ_CP090715:2005443-2005742 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAATATTTCGAAGC
CTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATTCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References