Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3139304..3141078 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag JN145_RS14970 Protein ID WP_003414409.1
Coordinates 3139304..3140188 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag JN145_RS14975 Protein ID WP_003414414.1
Coordinates 3140191..3141078 (-) Length 296 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS14950 3134559..3134933 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
JN145_RS14955 3134930..3137368 - 2439 WP_031667895.1 type III-A CRISPR-associated protein Cas10/Csm1 -
JN145_RS14960 3137365..3138153 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
JN145_RS14965 3138487..3139032 - 546 WP_003904931.1 DUF1802 family protein -
JN145_RS14970 3139304..3140188 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN145_RS14975 3140191..3141078 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JN145_RS14980 3141383..3141928 - 546 WP_003899500.1 DUF1802 family protein -
JN145_RS14985 3141925..3142194 - 270 WP_003414489.1 DUF2277 family protein -
JN145_RS14990 3142215..3142607 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
JN145_RS14995 3142604..3142819 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN145_RS15000 3142866..3143615 + 750 WP_003414497.1 enoyl-CoA hydratase -
JN145_RS15005 3143694..3144776 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T189268 WP_003414409.1 NZ_CP069068:c3140188-3139304 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp

>T189268 NZ_CP090715:c326828-326478 [Burkholderia multivorans]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTAAGCCTGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTCGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCCCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAAAGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT189268 WP_003414414.1 NZ_CP069068:c3141078-3140191 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp

>AT189268 NZ_CP090715:c327073-326822 [Burkholderia multivorans]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGTGCGGCGGTTCGCTTGCCCAGCGTTCTGCTCGAACAGATCAACGCGAC
GGTCGGCAGTTCGCTGAGTGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6Y56


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References