189261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 2872788..2873419 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag JN145_RS13510 Protein ID WP_003413174.1
Coordinates 2873042..2873419 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U8Y8P4
Locus tag JN145_RS13505 Protein ID WP_003909690.1
Coordinates 2872788..2873045 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS13470 2868046..2868360 + 315 WP_009937839.1 hypothetical protein -
JN145_RS13475 2868656..2869867 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
JN145_RS13480 2869994..2870653 + 660 WP_003900846.1 LppA family lipoprotein -
JN145_RS13485 2870650..2871309 + 660 WP_003900847.1 LppA family lipoprotein -
JN145_RS13490 2871306..2871968 + 663 WP_003900848.1 LppA family lipoprotein -
JN145_RS13495 2871965..2872243 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
JN145_RS13500 2872336..2872749 + 414 WP_003413164.1 PIN domain nuclease -
JN145_RS13505 2872788..2873045 + 258 WP_003909690.1 CopG family transcriptional regulator Antitoxin
JN145_RS13510 2873042..2873419 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS13515 2873435..2873809 - 375 WP_003413177.1 hypothetical protein -
JN145_RS13520 2873909..2874304 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
JN145_RS13525 2874301..2874546 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
JN145_RS13530 2874957..2875376 - 420 WP_003413190.1 A24 family peptidase -
JN145_RS13535 2875388..2876197 - 810 WP_003413193.1 shikimate dehydrogenase -
JN145_RS13540 2876194..2877447 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
JN145_RS13545 2877440..2877952 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T189261 WP_003413174.1 NZ_CP069068:2873042-2873419 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T189261 NZ_CP090708:1272685-1272981 [Burkholderia multivorans]
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9511.67 Da        Isoelectric Point: 10.2895

>AT189261 WP_003909690.1 NZ_CP069068:2872788-2873045 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRDSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT189261 NZ_CP090708:1272983-1273384 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAATTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8Y8P4

References