189258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2811613..2812265 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN145_RS13215 Protein ID WP_003412752.1
Coordinates 2811840..2812265 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U8TSR0
Locus tag JN145_RS13210 Protein ID WP_003909675.1
Coordinates 2811613..2811834 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS13195 2809853..2810059 - 207 WP_003899347.1 hypothetical protein -
JN145_RS13200 2810195..2810818 + 624 WP_003900858.1 TIGR00725 family protein -
JN145_RS13205 2810808..2811560 + 753 WP_003901416.1 hypothetical protein -
JN145_RS13210 2811613..2811834 + 222 WP_003909675.1 hypothetical protein Antitoxin
JN145_RS13215 2811840..2812265 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS13220 2812288..2813469 - 1182 WP_244749706.1 dihydrolipoamide acetyltransferase family protein -
JN145_RS13225 2813466..2814512 - 1047 WP_003909676.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN145_RS13230 2814523..2815626 - 1104 WP_003909677.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN145_RS13235 2815885..2816706 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN145_RS13240 2816703..2817260 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189258 WP_003412752.1 NZ_CP069068:2811840-2812265 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189258 NZ_CP090708:c427220-426921 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAATATTTCGAAGC
CTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATTCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7863.99 Da        Isoelectric Point: 5.0323

>AT189258 WP_003909675.1 NZ_CP069068:2811613-2811834 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDKD

Download         Length: 222 bp

>AT189258 NZ_CP090708:c427541-427224 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8TSR0

References