189257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2408203..2408732 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN145_RS11315 Protein ID WP_003411124.1
Coordinates 2408203..2408520 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN145_RS11320 Protein ID WP_003411127.1
Coordinates 2408517..2408732 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS11285 2403224..2404300 + 1077 WP_003411110.1 hypothetical protein -
JN145_RS11290 2404297..2404578 + 282 WP_003411112.1 DUF5703 family protein -
JN145_RS11295 2404614..2405687 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN145_RS11300 2405692..2406222 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN145_RS11305 2406270..2407616 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN145_RS11315 2408203..2408520 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN145_RS11320 2408517..2408732 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN145_RS11325 2408987..2410045 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN145_RS11330 2410175..2410531 - 357 WP_003411130.1 hypothetical protein -
JN145_RS11335 2410626..2411408 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN145_RS11340 2411676..2411966 - 291 WP_003900476.1 YggT family protein -
JN145_RS11345 2412128..2412784 - 657 WP_003411133.1 cell division protein SepF -
JN145_RS11350 2412850..2413626 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189257 WP_003411124.1 NZ_CP069068:c2408520-2408203 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189257 NZ_CP090707:c3300046-3299645 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGCTATGCACCAATC
CTGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGTTGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189257 WP_003411127.1 NZ_CP069068:c2408732-2408517 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189257 NZ_CP090707:c3300282-3300046 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References