189255

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 2327512..2328148 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag JN145_RS10915 Protein ID WP_003410654.1
Coordinates 2327738..2328148 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag JN145_RS10910 Protein ID WP_003410651.1
Coordinates 2327512..2327745 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS10895 2322960..2323361 + 402 WP_009937711.1 metal ABC transporter permease -
JN145_RS10900 2323362..2323766 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
JN145_RS10905 2323850..2327434 - 3585 WP_003410648.1 cobaltochelatase subunit CobN -
JN145_RS10910 2327512..2327745 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
JN145_RS10915 2327738..2328148 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
JN145_RS10920 2328132..2329223 + 1092 WP_003900454.1 precorrin-3B synthase -
JN145_RS10925 2329233..2329859 + 627 WP_003410658.1 precorrin-8X methylmutase -
JN145_RS10930 2329856..2331382 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
JN145_RS10935 2331328..2332551 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T189255 WP_003410654.1 NZ_CP069068:2327738-2328148 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

>T189255 NZ_CP090707:736777-737190 [Burkholderia multivorans]
ATGAGCGGGGCTGACAAGGCGAAAGTGTTTGTGGACAGCAATGTCGTGCTGTATCTGCTGTCCGGCGACGCCGCGAAGGC
GGATCGTGCGGAGGCTCTGTTGCGGCGCCGGCCGACGATCAGCGTTCAGGTGCTGAACGAAGTCACGAATGTCTGCGTGC
GTAAGCTCGGGATGGCGTGGCGTGAGGTCGATCAGTTCCTGGAACTGGTGCGGCAGTTTTGCGTGGTCGCGCCGCTGACA
ATCGAGATGCATGATTTGGCGCGGCGCATCGCCGAGCGCTATGGCCTGGCGTTCTATGATGCGTGCATCGTAGCAGCCGC
GTCGATCGAAGGATGCCACGCCCTCTACACGGAAGACATGCATCACGGATTGATCATCGAAGAGAGCTTGACGTTGCGTA
ACCCTTTCGCGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT189255 WP_003410651.1 NZ_CP069068:2327512-2327745 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp

>AT189255 NZ_CP090707:736557-736790 [Burkholderia multivorans]
ATGCAGGTTGCTAAATGGGGCAATAGCCTTGCCGTCCGCCTTCCGTCGAGCCTGGTCGAAGCGCTCGAGCTGCGTGAGGG
GGACGATATCGAGATCGTCATAGACGCGCCGCGCACCTTTGCGGTACGCAAGAAACCGGGGGCGGATGAGCTGCTGGAGC
GGTTGCGCCACTTCCGCGGCAAGCTGCCGGCCGATTTCAAGTTCAGCCGGGACGAGGCGAATGAGCGGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BV50

References