189250

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2230408..2231096 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN145_RS10470 Protein ID WP_003409958.1
Coordinates 2230408..2230827 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN145_RS10475 Protein ID WP_003409968.1
Coordinates 2230836..2231096 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS10445 2225758..2226036 - 279 WP_003907828.1 hypothetical protein -
JN145_RS10450 2226166..2226813 - 648 WP_003909553.1 PE family protein -
JN145_RS10455 2227593..2228192 + 600 WP_234776458.1 hypothetical protein -
JN145_RS10460 2228338..2229024 - 687 WP_003909555.1 immunoprotective protein Mpt64 -
JN145_RS10465 2229215..2230183 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN145_RS10470 2230408..2230827 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS10475 2230836..2231096 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN145_RS10480 2231239..2232915 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN145_RS10485 2232903..2233556 - 654 WP_003409976.1 cutinase Cfp21 -
JN145_RS10490 2233671..2233901 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN145_RS10495 2233986..2234897 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN145_RS10500 2235006..2235605 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189250 WP_003409958.1 NZ_CP069068:c2230827-2230408 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189250 NZ_CP090705:1200017-1200313 [Burkholderia multivorans]
ATGGAAAAGCGAACGGCGCACTGCAAGCTGCCGCGCGTCAAGGCGTTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189250 WP_003409968.1 NZ_CP069068:c2231096-2230836 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189250 NZ_CP090705:1200315-1200716 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAATTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References