189249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2210124..2210668 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN145_RS10350 Protein ID WP_003409896.1
Coordinates 2210124..2210420 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN145_RS10355 Protein ID WP_003409899.1
Coordinates 2210417..2210668 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS10295 2205157..2205507 - 351 WP_003409871.1 hypothetical protein -
JN145_RS10300 2205518..2206420 - 903 WP_003409874.1 hypothetical protein -
JN145_RS10305 2206441..2206632 - 192 WP_003409876.1 hypothetical protein -
JN145_RS10310 2206633..2206929 - 297 WP_003409877.1 hypothetical protein -
JN145_RS10315 2207169..2207384 + 216 WP_003409878.1 antitoxin -
JN145_RS10320 2207381..2207692 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN145_RS10325 2207666..2208187 - 522 WP_003904745.1 hypothetical protein -
JN145_RS10330 2208162..2208539 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN145_RS10335 2208581..2209030 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN145_RS10340 2209027..2209572 + 546 WP_003409891.1 SecB-like chaperone -
JN145_RS10345 2209461..2210075 - 615 WP_003901296.1 hypothetical protein -
JN145_RS10350 2210124..2210420 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN145_RS10355 2210417..2210668 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN145_RS10360 2210655..2211149 + 495 WP_003899099.1 hypothetical protein -
JN145_RS10365 2211309..2211716 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN145_RS10370 2211720..2211992 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN145_RS10375 2212025..2213245 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN145_RS10380 2214144..2214941 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189249 WP_003409896.1 NZ_CP069068:c2210420-2210124 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189249 NZ_CP090705:1023915-1024490 [Burkholderia multivorans]
ATGACGCATTCGCCATTTACGGCGATCTACGATGCCTGTGTGCTTTATCCCGCGCCGCTTCGCGATTTCCTGATGCGGCT
GGCGTTGAGTGGATGTTTCCGGGCGCGGTGGAGCGCACATATTACCGACGAGTGGAAGCGCAATCTGTTGGACAACCGTC
CGGATTTGACAGCGGAACAGCTTGATCGAACCTCAAGTTTGATGGATCGAGCGATACCGGATGCCGTCGTGACCGGTTAT
GAATCGTTGATTGCCGGGCTTGTTCTCCCGGATGCCGACGATCGTCACGTGCTTACCGCTGCAATCCGTTGCAACGCCAG
CGTGATCGTGACGTTCAATCGAAAGGACTTTCCGGAAGAGGCGTTGTTGCCGTACGGCATCGAGGCCCAGCATCCAGACG
AGTTCGTCGATGATCTTTTCGACCTCGAACCCGCGGTGGTCGTTGCGGCCGCGCGACGACAGCGAGAGGCGCTTAAACAA
CCACCGTTGACTGCAGACCGGTACCTCGAGATCTTGCGACGACAAGGCATGGTGCAGACGTGTCAGTCGCTCGACGCCTA
TCGAGCACTTCTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189249 WP_003409899.1 NZ_CP069068:c2210668-2210417 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189249 NZ_CP090705:1023451-1023918 [Burkholderia multivorans]
ATGCATCACGCCACGACACCCGACATGATCTTGCCCGTCGAGCGCGAGATGCAGGCGGCCGTCGAGGCGCAGCGCATGCT
GGCGGCTTATCTCGCAACACGGACCGATACGCAGCGCATTCAGATTTTTGATGACGAGAACCGAGCCCATCAGGTCGAGC
TGCCGACGTCCGCACTTCGTCTGCTGGTGGATATTCTCGCGGAATTGGCGGATGGCAACGCTGTCAAGGTTGTGCCGGTT
CATGCGGAATTGACGACGCAGGAAGCGGCAGATCTGCTCAATGTCTCCCGCCCGCATCTGATCAAGCTGCTTGAGTCGAA
TGCATTGCCCTATCACCGGACGGGCAAGCATCGGCGCGTGCGGTTTTCGGATCTGATGCGCTACAAGGCTGAGCGCGACC
AAGAGAGTGCTGACGCAATGGAAGAACTGAGCAAGCAGGCACAGGATCTGCGGATGGGCTATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References