189246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1982078..1982538 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JN145_RS09290 Protein ID WP_003898996.1
Coordinates 1982290..1982538 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JN145_RS09285 Protein ID WP_003408528.1
Coordinates 1982078..1982290 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS09270 1978556..1979743 - 1188 WP_003898992.1 nitrate transporter NarK -
JN145_RS09275 1980030..1980314 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JN145_RS09280 1980328..1982010 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JN145_RS09285 1982078..1982290 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN145_RS09290 1982290..1982538 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS09295 1982546..1983284 + 739 Protein_1834 hypothetical protein -
JN145_RS09300 1983378..1985078 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JN145_RS09305 1985363..1985764 - 402 WP_003408538.1 hypothetical protein -
JN145_RS09310 1985754..1986365 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T189246 WP_003898996.1 NZ_CP069068:1982290-1982538 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T189246 NZ_CP090703:2404924-2405301 [Burkholderia multivorans]
ATGGGTATAAATTCATCGATGGTTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGCGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT189246 WP_003408528.1 NZ_CP069068:1982078-1982290 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT189246 NZ_CP090703:2405301-2405624 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTTGGCACGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATCGCGGAAATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCACGATTGCTCGGCATGA
CGCAACCGAAGTTATCGAACATGCTGCGCGGGCAGTTTCGCGGTGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References