189245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1961403..1962016 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JN145_RS09180 Protein ID WP_003408465.1
Coordinates 1961403..1961792 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JN145_RS09185 Protein ID WP_003408469.1
Coordinates 1961789..1962016 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS09145 1957032..1957946 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JN145_RS09150 1957949..1958779 + 831 WP_003408448.1 cyclase family protein -
JN145_RS09155 1958779..1959129 + 351 WP_003898986.1 cupin domain-containing protein -
JN145_RS09160 1959182..1960000 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JN145_RS09165 1960014..1960793 + 780 WP_003408460.1 IclR family transcriptional regulator -
JN145_RS09175 1961224..1961355 + 132 Protein_1810 IS3 family transposase -
JN145_RS09180 1961403..1961792 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS09185 1961789..1962016 - 228 WP_003408469.1 antitoxin Antitoxin
JN145_RS09190 1962234..1963718 + 1485 WP_003408473.1 biotin carboxylase -
JN145_RS09195 1963715..1964962 + 1248 WP_003408476.1 serine hydrolase -
JN145_RS09200 1965005..1965424 - 420 WP_003408483.1 hypothetical protein -
JN145_RS09205 1965414..1966124 - 711 WP_003909499.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T189245 WP_003408465.1 NZ_CP069068:c1961792-1961403 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T189245 NZ_CP090703:77717-78118 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGCTATGCACCAATC
CTGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTGGCGCCGTTCGACGTTGCGGCTGCGCAGGCA
TACGGCCCCATTCGAGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCCGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTGGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT189245 WP_003408469.1 NZ_CP069068:c1962016-1961789 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT189245 NZ_CP090703:77481-77717 [Burkholderia multivorans]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTTGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGGTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References