189233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843789..844498 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag JN145_RS03990 Protein ID WP_003403837.1
Coordinates 844070..844498 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag JN145_RS03985 Protein ID WP_003403834.1
Coordinates 843789..844046 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS03980 841004..843698 + 2695 Protein_787 PE family protein -
JN145_RS03985 843789..844046 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
JN145_RS03990 844070..844498 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
JN145_RS03995 844579..844716 - 138 WP_003403839.1 hypothetical protein -
JN145_RS04005 844875..845120 + 246 WP_003403841.1 hypothetical protein -
JN145_RS04010 845189..846073 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
JN145_RS04015 846084..847256 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
JN145_RS04020 847263..848795 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T189233 WP_003403837.1 NZ_CP069068:844070-844498 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T189233 NZ_CP090699:c952630-952268 [Burkholderia cepacia]
ATGGATCCGTACATCAAACCGCTGTACTGGCTCGGTTCGGCGCTTAAGGACCTGAAAGCGATGCCCGATGCCGTACAGGA
CACGGTCGGATATGCGCTGTACCTGGCGCAGACGGGACGAAAGCACGATCACGCCAAGCCGTTGAGGGGCTTCGGATCGG
CCGGCGTGCTCGAGATCGTGGAATCGGAAGACAACGGCACGTACCGCGCCGTCTACACCGTGAAGCTCGGGAACAGCGTG
TACGTGCTGCACAGCTTCCAGAAAAAATCGTCGAGCGGCATCGCGACACCGAAGCCGGACGTCGATCTGATCCGTGAACG
CCTGAAAGCAGCCGAAGCACACGCAAAAGGAGAAAGTCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT189233 WP_003403834.1 NZ_CP069068:843789-844046 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT189233 NZ_CP090699:c952271-951948 [Burkholderia cepacia]
ATGATCGAAATCGAGCAGGGCAGCGGTAACGTCTACGCCGATCTGGGTAGGCACGATGCCGACGAAATGCTTGTGAAGGC
GCAACTCGCCGCCAAGATCGCCGAGATCATCAAGGCGCGCAAATGGACGCAGCAGCATGCCGCGCGATTGCTCGGCATGA
CGCAACCGAAACTGTCGAACATGCTGCGCGGACAGTTTCGCGGCGTGAGCGAAACGAAGATGATCGAGTGTCTGGCGAAG
CTCGGGCGCGACGTGCAGATCGTCGTCGGACCCGACCGTCATTCGGAAATCGAGGGGCACATCGAAGTCGTATTCGCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References