189227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 718398..719047 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN145_RS03300 Protein ID WP_003403236.1
Coordinates 718652..719047 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN145_RS03295 Protein ID WP_003403235.1
Coordinates 718398..718652 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS03270 713523..713606 + 84 Protein_648 galactose-1-phosphate uridylyltransferase -
JN145_RS03275 713625..714707 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN145_RS03280 714704..715795 + 1092 WP_003900977.1 galactokinase -
JN145_RS03285 716190..717347 + 1158 WP_003903091.1 hypothetical protein -
JN145_RS03290 717358..718305 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN145_RS03295 718398..718652 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN145_RS03300 718652..719047 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN145_RS03305 719141..719881 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN145_RS03310 720013..720273 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN145_RS03315 720270..720677 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN145_RS03320 720749..721900 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
JN145_RS03325 721993..723720 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189227 WP_003403236.1 NZ_CP069068:718652-719047 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189227 NZ_CP090698:1573966-1574382 [Burkholderia cepacia]
GTGTATTTGATTGATACCAACGTCATCAGTGAAATCAGGAAGGGCAAGCGAACCAACCGTGGCGTGCGGGCGTTCTTCAG
GCAGGCCGCGGCGGACGCCAGCCCGCTTTACCTGTCCGTCGTGACAGTTGCTGAACTTCGCCGCGGCGTCGACCTGATCC
GTCATCGCGGCGATCACCCCCAGGCGTCGGCGCTCGAGGCCTGGGTGGCAATGATCCTGGCCGGCTATGCACCGAACATC
CTGCCGGTCGACATCGAGATCAGCCAGACGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACCGTGGTTACGCGCAACGTCGCGGATTTCGCCCGCACCGGCGTCAGGTTGC
TGAACCCGTTCGACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189227 WP_003403235.1 NZ_CP069068:718398-718652 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189227 NZ_CP090698:1573743-1573979 [Burkholderia cepacia]
ATGGCAAATCTACTGGTACGTAACGTGGATGACAATATCGTTCAGAGCCTGCGTGAGCGGGCTGCGGCAAATGGCCGGAG
TGCCGAGGCCGAACATCGGGCCATTCTGGCCGATGCGCTCGGCAGGCCGAAGCGAAAGACATTTGCGCAAGTGCTGATGA
GCATGCCCGATGTCGGCGAAGACGCGGATTTTCAACGTATTCAGGATTCCGGCGAGGCCAGGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References