189226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712769..713394 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN145_RS03265 Protein ID WP_003403218.1
Coordinates 712993..713394 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN145_RS03260 Protein ID WP_003403213.1
Coordinates 712769..712996 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS03235 707948..708169 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN145_RS03240 708311..708916 + 606 WP_003898526.1 hypothetical protein -
JN145_RS03245 708935..711502 - 2568 WP_003909263.1 SEC-C metal-binding domain-containing protein -
JN145_RS03250 711586..712335 + 750 WP_244749807.1 hypothetical protein -
JN145_RS03255 712332..712574 + 243 WP_003403210.1 hypothetical protein -
JN145_RS03260 712769..712996 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN145_RS03265 712993..713394 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN145_RS03270 713523..713606 + 84 Protein_648 galactose-1-phosphate uridylyltransferase -
JN145_RS03275 713625..714707 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN145_RS03280 714704..715795 + 1092 WP_003900977.1 galactokinase -
JN145_RS03285 716190..717347 + 1158 WP_003903091.1 hypothetical protein -
JN145_RS03290 717358..718305 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T189226 WP_003403218.1 NZ_CP069068:712993-713394 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T189226 NZ_CP090698:1210988-1211884 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGCGAGCGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGTGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAACAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTTGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGTTATGTCGAGGCGCCGGCCGTCTATTCCGCGCTGATCGACTCGTTCTGCCGTCATTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT189226 WP_003403213.1 NZ_CP069068:712769-712996 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT189226 NZ_CP090698:1211881-1212738 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCTGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGAGACGTGGTGTTCGTCGCGAAGGCAC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCACTGAAGGAGCTGCGCTCGTTGTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCGTTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAAATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References