Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
| Location | 699137..699783 | Replicon | chromosome |
| Accession | NZ_CP069068 | ||
| Organism | Mycobacterium tuberculosis strain N1272 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ88 |
| Locus tag | JN145_RS03160 | Protein ID | WP_003403137.1 |
| Coordinates | 699137..699550 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ89 |
| Locus tag | JN145_RS03165 | Protein ID | WP_003403139.1 |
| Coordinates | 699547..699783 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN145_RS03140 | 695220..696770 | + | 1551 | WP_003403119.1 | MlaD family protein | - |
| JN145_RS03145 | 696822..697214 | - | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
| JN145_RS03150 | 697211..697468 | - | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
| JN145_RS03155 | 697651..698886 | - | 1236 | WP_003403128.1 | ATP-binding protein | - |
| JN145_RS03160 | 699137..699550 | - | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JN145_RS03165 | 699547..699783 | - | 237 | WP_003403139.1 | type II toxin-antitoxin system antitoxin VapB27 | Antitoxin |
| JN145_RS03170 | 699887..700393 | - | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
| JN145_RS03175 | 700507..701037 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
| JN145_RS03180 | 701021..701716 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
| JN145_RS03185 | 701839..702150 | + | 312 | WP_003403164.1 | hypothetical protein | - |
| JN145_RS03190 | 702222..703175 | + | 954 | WP_244749805.1 | DUF1259 domain-containing protein | - |
| JN145_RS03195 | 703416..704000 | + | 585 | WP_031667543.1 | IS607-like element IS1536 family transposase | - |
| JN145_RS03200 | 704002..704713 | + | 712 | Protein_634 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T189224 WP_003403137.1 NZ_CP069068:c699550-699137 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
>T189224 NZ_CP090698:c858149-857568 [Burkholderia cepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCGCAGCGCGACGAGATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCCGCAATCCGCCCGGTTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGAGCGGGCAGCACGCGTAA
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGTGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGCCGCTCGATCC
GGCGCAGCGCGACGAGATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCAAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCCGCAATCCGCCCGGTTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAACGCCGGATCGA
CGCGAGCGGGCAGCACGCGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8212.41 Da Isoelectric Point: 5.0351
>AT189224 WP_003403139.1 NZ_CP069068:c699783-699547 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
Download Length: 237 bp
>AT189224 NZ_CP090698:c858789-858232 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACACGCCGCCACTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAACAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAGTCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCACGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCTGTTCGCCTGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCCGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGTCGGCCGCGCGGCTCGTGGAAACGCTGTAG
ATGTCTGCCTCACCGCTACACACGCCGCCACTCGGCCCGCAACTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAACAGAG
CCACGCGGCGGAACTGTTCGGCGTGGCGCAGTCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGGCG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCACGCCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTCGCCTGTTCGCCTGCGCGTGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAACCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCCGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGTTGTCGGACGGGTCGGCCGCGCGGCTCGTGGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|