Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 679692..680311 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag JN145_RS03080 Protein ID WP_003403047.1
Coordinates 679904..680311 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag JN145_RS03075 Protein ID WP_003403039.1
Coordinates 679692..679907 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS03065 678220..678978 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
JN145_RS03070 679107..679598 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
JN145_RS03075 679692..679907 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
JN145_RS03080 679904..680311 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
JN145_RS03085 680371..681057 - 687 WP_003909258.1 LpqN/LpqT family lipoprotein -
JN145_RS03090 681211..683844 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T189222 WP_003403047.1 NZ_CP069068:679904-680311 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T189222 NZ_CP090698:173980-174261 [Burkholderia cepacia]
ATGACCTTTGAACTTGCCTTTCTCGAACCTGCATTGAAGGAGTGGAAGAAGCTCGATCGCACCGTGCGCGATCAATTCAA
GGCCAAGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCCGGATCGCTACAAGATCA
AGCTGCGTGGTGTCGGGTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGGTGGTCGCGGTCGGCCGC
CGCGAGCGTGATGCGGTTTATCTGGCTGCGATGAAACGCTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT189222 WP_003403039.1 NZ_CP069068:679692-679907 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT189222 NZ_CP090698:173742-173990 [Burkholderia cepacia]
ATGCCTCACACCATTCTGGCGAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCAGG
TGAAGGTTTTCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTACTGCATTCCCGCGAAGACGTGGGAGGCGATGG
TCGAACGTTTGGAAGACATCGAAGACAATGCGTTGGCCGATTCGCGCGCCAGGGAGAAGGTCGTCAAGGTTAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References