189219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 366019..366662 Replicon chromosome
Accession NZ_CP069068
Organism Mycobacterium tuberculosis strain N1272

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN145_RS01600 Protein ID WP_003401566.1
Coordinates 366237..366662 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN145_RS01595 Protein ID WP_003401563.1
Coordinates 366019..366240 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN145_RS01570 361093..361896 - 804 WP_003401540.1 Stf0 family sulphotransferase -
JN145_RS01575 361906..363303 - 1398 WP_003401544.1 sulfatase -
JN145_RS01580 363482..365302 + 1821 WP_003401546.1 PE family protein -
JN145_RS01585 365445..365672 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN145_RS01590 365669..365971 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN145_RS01595 366019..366240 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN145_RS01600 366237..366662 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN145_RS01605 366798..367430 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN145_RS01610 367427..368335 + 909 WP_003900117.1 protochlorophyllide reductase -
JN145_RS01615 368343..368933 - 591 WP_229298012.1 hypothetical protein -
JN145_RS01620 368926..368976 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T189219 WP_003401566.1 NZ_CP069068:366237-366662 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T189219 NZ_CP090696:1466137-1466502 [Burkholderia multivorans]
ATGGTAAAAGCCCTCTTCGACACCAACATCCTGATCGACTATCTGAGCGGCGTGGAGTCGGCCCGCCTGGAGCTCGGCCG
CTACGACCACCGTGCAATCAGCACCATTACGTGGATGGAAGTCCTGGTCGGTACGACCGCAGATGACGAAGGCCCGATTC
GCGCGTGGCTCTCGTCGTTCGACGTGATCCCGCTCGACATTACGGTTGCCGACCGCGCCGTGACCATTCGCAAGGAACGG
CGCATTCGTCTGCCCGACGCGATCGTCTGGGCATCAGCGCAGGTGAACGGACGCCTGCTCGTGTCGCGCAACACGAAAGA
CTTTCCCTCGACGGAACCCGGCATCCGGGTGCCTTACCAGATCTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT189219 WP_003401563.1 NZ_CP069068:366019-366240 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT189219 NZ_CP090696:1465925-1466143 [Burkholderia multivorans]
ATGAGCCGAGTCTTGGTGGATCTGTCGGACGGCCAGCTCGACGAGCTGGCCGTCATCGTCGAGACTGAGCATCGTCCTCG
CGCCGCGATCATTCGCGATGCGATTGACGCCTACATCGCCCTACACAAGCGCCCGCTCGCCGACGATGTCTTCGGCCTCT
GGAAAGACCGCGCCGTCGACGGGCTCGCTTATCAGGAAAAACTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References