Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3197019..3197706 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag JN146_RS15245 Protein ID WP_003414624.1
Coordinates 3197263..3197706 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag JN146_RS15240 Protein ID WP_003414620.1
Coordinates 3197019..3197276 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS15220 3192339..3193193 - 855 WP_244748596.1 GNAT family N-acetyltransferase -
JN146_RS15225 3193249..3194412 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN146_RS15230 3194429..3195643 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN146_RS15235 3195651..3196892 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
JN146_RS15240 3197019..3197276 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
JN146_RS15245 3197263..3197706 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
JN146_RS15250 3197786..3198448 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
JN146_RS15255 3198544..3198735 + 192 WP_003909769.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JN146_RS15260 3199067..3200815 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
JN146_RS15265 3200911..3201492 + 582 WP_003414644.1 fasciclin domain-containing protein -
JN146_RS15270 3201592..3201858 + 267 WP_031667416.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T189210 WP_003414624.1 NZ_CP069067:3197263-3197706 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T189210 NZ_CP090694:c1137716-1137420 [Burkholderia multivorans]
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAATCGGAAACGATCGACGTGGTGAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTC
TATCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT189210 WP_003414620.1 NZ_CP069067:3197019-3197276 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT189210 NZ_CP090694:c1137418-1137017 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCGCGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACGGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAAGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCAGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGGAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References