189209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3191418..3191966 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JN146_RS15215 Protein ID WP_003414602.1
Coordinates 3191703..3191966 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JN146_RS15210 Protein ID WP_003414599.1
Coordinates 3191418..3191699 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS15185 3187041..3187898 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JN146_RS15190 3187940..3188524 - 585 WP_003414585.1 DUF1707 domain-containing protein -
JN146_RS15195 3188628..3188876 + 249 WP_003913411.1 antitoxin VapB23 -
JN146_RS15200 3188873..3189253 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JN146_RS15205 3189335..3191146 - 1812 WP_003414596.1 penicillin-binding protein -
JN146_RS15210 3191418..3191699 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JN146_RS15215 3191703..3191966 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN146_RS15220 3192339..3193193 - 855 WP_244748596.1 GNAT family N-acetyltransferase -
JN146_RS15225 3193249..3194412 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN146_RS15230 3194429..3195643 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN146_RS15235 3195651..3196892 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T189209 WP_003414602.1 NZ_CP069067:3191703-3191966 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T189209 NZ_CP090694:875888-876784 [Burkholderia multivorans]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGCGCGGCGGGCACGATCGGGTATCGCGAGGCCGGTGCGCAGCATGCCGGCGCCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCGTCGCCGTCGGCCGTCGATTACGCGGCGTCGCTCGACGC
GTGGCTCGATGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGGATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGCGCGCCGGCCGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTTGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAAGACGCGCGCGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCTGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCCGCCGATCTCGCCGGGTTTCGCGGCCGCACGGCGGTGGCCGTCGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGCGAACGAATCGCGGCGGCGGCCGGCGTCGGACTGCAGGTGATTCCACA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCGGACGTCTATTCGGCCTTGATCGACACGTTCTGCCGGCAGTGCGACATCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT189209 WP_003414599.1 NZ_CP069067:3191418-3191699 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT189209 NZ_CP090694:876781-877635 [Burkholderia multivorans]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAACCCGCGAAGGCCGAAGCGAGCTACGTCGTGCCGGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGTGCGCCGGAGTTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCCAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTCTCGCTGGACGAGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGATGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGCATTTCGGTCGTCACCGCGCCGGTACGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGACGGGCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAGCACACGTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWP8

References