Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2420094..2420623 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN146_RS11350 Protein ID WP_003411124.1
Coordinates 2420094..2420411 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN146_RS11355 Protein ID WP_003411127.1
Coordinates 2420408..2420623 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS11320 2415115..2416191 + 1077 WP_003411110.1 hypothetical protein -
JN146_RS11325 2416188..2416469 + 282 WP_003411112.1 DUF5703 family protein -
JN146_RS11330 2416505..2417578 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN146_RS11335 2417583..2418113 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN146_RS11340 2418161..2419507 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN146_RS11350 2420094..2420411 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN146_RS11355 2420408..2420623 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN146_RS11360 2420878..2421936 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN146_RS11365 2422066..2422422 - 357 WP_003411130.1 hypothetical protein -
JN146_RS11370 2422517..2423299 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN146_RS11375 2423567..2423857 - 291 WP_003900476.1 YggT family protein -
JN146_RS11380 2424019..2424675 - 657 WP_003411133.1 cell division protein SepF -
JN146_RS11385 2424741..2425517 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189196 WP_003411124.1 NZ_CP069067:c2420411-2420094 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189196 NZ_CP090688:1228328-1228624 [Burkholderia multivorans]
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTAAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TATCTGAAACTGACCGTCATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189196 WP_003411127.1 NZ_CP069067:c2420623-2420408 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189196 NZ_CP090688:1228626-1229027 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCGCGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACGGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGGCGAGGCGACCCGTTTCG
GCGAAGCAGTGTCGGCGTTCAACCGGCAAGTGAACGCGACACTCGTTGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCACTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References