Detailed information of TA system TA189196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2420094..2420623
• Replicon: chromosome
• Accession: NZ_CP069067
• Organism: Mycobacterium tuberculosis strain N1268

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: JN146_RS11350
• Protein ID: WP_003411124.1
• Coordinates: 2420094..2420411 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: JN146_RS11355
• Protein ID: WP_003411127.1
• Coordinates: 2420408..2420623 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN146_RS11320	2415115..2416191	+	1077	WP_003411110.1	hypothetical protein	-
JN146_RS11325	2416188..2416469	+	282	WP_003411112.1	DUF5703 family protein	-
JN146_RS11330	2416505..2417578	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
JN146_RS11335	2417583..2418113	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
JN146_RS11340	2418161..2419507	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
JN146_RS11350	2420094..2420411	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN146_RS11355	2420408..2420623	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
JN146_RS11360	2420878..2421936	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
JN146_RS11365	2422066..2422422	-	357	WP_003411130.1	hypothetical protein	-
JN146_RS11370	2422517..2423299	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
JN146_RS11375	2423567..2423857	-	291	WP_003900476.1	YggT family protein	-
JN146_RS11380	2424019..2424675	-	657	WP_003411133.1	cell division protein SepF	-
JN146_RS11385	2424741..2425517	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T189196 WP_003411124.1 NZ_CP069067:c2420411-2420094 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T189196 NZ_CP090688:1228328-1228624 [Burkholderia multivorans]
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTAAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TATCTGAAACTGACCGTCATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT189196 WP_003411127.1 NZ_CP069067:c2420623-2420408 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT189196 NZ_CP090688:1228626-1229027 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCGCGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACGGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGGCGAGGCGACCCGTTTCG
GCGAAGCAGTGTCGGCGTTCAACCGGCAAGTGAACGCGACACTCGTTGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCACTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4